Abstract
Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Antidotes / chemistry
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Antidotes / pharmacology*
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Antigens, Bacterial
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Bacterial Toxins / antagonists & inhibitors*
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Rats
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Structure-Activity Relationship
Substances
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Antidotes
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Antigens, Bacterial
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Bacterial Toxins
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anthrax toxin